Structure of Retroviral Particles as a Tool for Designing HIV Inhibitors

Authors

  • P. Ulbrich Department of Biochemistry and Microbiology, Institute of Chemical Technology, Prague
  • T. Füzik Department of Biochemistry and Microbiology, Institute of Chemical Technology, Prague
  • R. Píchalová Department of Biochemistry and Microbiology, Institute of Chemical Technology, Prague
  • I. Voráčková Department of Biochemistry and Microbiology, Institute of Chemical Technology, Prague
  • T. Ruml Department of Biochemistry and Microbiology, Institute of Chemical Technology, Prague

Keywords:

retrovirus, retroviral particle assembly, retroviral particle structure, HIV, M-PMV, electron microscopy, cryo-electron microscopy

Abstract

This article describes basic principles of retroviral shell architecture and the approaches to its studies. Elucidation of the retrovirus particle structure, both in immature and mature forms, is essential for designing compounds that could block interactions at interfaces of viral proteins, which are critical for formation and stability of the particle. Detailed understanding of HIV structure could thus be a significant tool in the search for novel types of HIV inhibitors targeted on the assembly or maturation of this virus.

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Published

2012-10-15

How to Cite

Ulbrich, P., Füzik, T., Píchalová, R., Voráčková, I., & Ruml, T. (2012). Structure of Retroviral Particles as a Tool for Designing HIV Inhibitors. Chemické Listy, 106(10), 911–919. Retrieved from http://www-.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/831

Issue

Vol. 106 No. 10 (2012)

Section

Articles